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◆ Human Body & Mind · Genetics

Watson and Crick crack the DNA double helix

On this day · 28 February 1953
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On a single Saturday morning in Cambridge, two scientists worked out the twisted-ladder shape that encodes all life.

Verified · National Library of Medicine (PMC)

On 28 February 1953, in Cambridge’s Cavendish Laboratory, James Watson and Francis Crick finished puzzling out that DNA is a double helix — two strands winding around each other like a spiral staircase. By lunchtime Crick was reportedly telling drinkers at the Eagle pub that the pair had “found the secret of life.”

The whole point was the pairing: A always bonds to T, G to C, so each strand is a template to copy the other.

The insight leaned heavily on X-ray diffraction images produced by Rosalind Franklin and Maurice Wilkins at King’s College London. Franklin’s data was crucial, yet she received little public credit at the time, and she died in 1958 — before the 1962 Nobel Prize went to Watson, Crick, and Wilkins.

Their formal announcement came as a famously terse paper in Nature on 25 April 1953: roughly 800 words and a single figure, ending with the sly understatement that the structure suggested “a possible copying mechanism for the genetic material.”

800
words in the Nature paper
1962
Nobel Prize awarded

Sources & references

2 references

Well-established. Corroborated by 2 independent sources.

1 National Library of Medicine (PMC) Government medical library “After 18 months of tireless effort, Watson, then 24, and Crick, then 36, made their groundbreaking discovery in Cambridge, England, on 28 February 1953... the initial publication of the DNA model on 25 April 1953 was notable for its conciseness: it included just 800 words and one figure.” pmc.ncbi.nlm.nih.gov ↗
2 Scientific American Science media “On that Saturday morning, February 28, 1953, at The Eagle pub in Cambridge, Watson and Crick worked out the double helix structure of DNA; Crick proclaimed they had 'discovered the secret of life.' They published in the April 25, 1953 issue of Nature.” scientificamerican.com ↗
✓ Last reviewed Jun 7, 2026

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